THE STATISTICAL SLEUTH: A COURSE IN METHODS OF DATA ANALYSIS, Third Edition offers an appealing treatment of general statistical methods that takes full advantage of the computer, both as a computational and an analytical tool. The material is independent of any specific software package, and prominently treats modeling and interpretation in a way that goes beyond routine patterns. The book focuses on a serious analysis of real case studies, strategies and tools of modern statistical data analysis, the interplay of statistics and scientific learning, and the communication of results. With interesting examples, real data, and a variety of exercise types (conceptual, computational, and data problems), the authors get readers excited about statistics.
Absolute garbage but seems to be the book of choice for beginning statistics courses for scientists. The authors' attempt to simplify statistics is abysmal (come on, a train analogy to explain PCA). They leave out the math, fundamental to understanding this subject, and replace it with pathetic analogies and examples. One gets a precursory, if that, understanding of the subject from reading the text, but the material is so slick in presentation and overly simplified that one must read it multiple times to get all out of it that's necessary to actually conduct an analysis. For a good general statistics book, buy Biometry, or if you want something in a similar style, buy Ellison's A Primer of Ecological Statistics (he actually seems to understand that people reading statistics texts aren't generally morons).
I didn't read the whole thing, just skimmed it while looking for datasets to use in homework problems for my Experimental Design course. But it looks to be well-written, with good explanations and really nice use of extended case studies that tie different topics together. I might try it as a textbook next time.