Evidence-based research (EBR) is central to the advancement of science, healthcare, and public policy. However, its effectiveness is often compromised by a range of recurring pitfalls that can distort findings, undermine reproducibility, and erode public trust. This review identifies and critically examines 28 common pitfalls of EBR, categorized into five domains: methodological, statistical, ethical and reporting, human-related, and institutional. Each pitfall is explored with clear definitions, illustrative examples, and actionable… Read More »The 28 Pitfalls of Evidence-Based Research: A Scientific Review of Challenges and Mitigation Strategies